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- W2377747403 abstract "Objective To investigate whether the Smad4 gene exists in the cochlea of postnatal mice and to detect its expression and distribution in the cochlea. Methods We prepared frozen sections of cochleae from three monse genotypes: Smad4 (+/+), Smad4 (+/-) and Smad4 (-/-). Smad4 expression of the cochlea was detected by immunohistochemical technique. As a negative control, frozen sections of the cochlea were obtained from wild-type mice with no antibodies and a positive control, frozen sections of mouse kidney were used. Results Smad4 genes were expressed throughout the postnatal cochlea of three mouse genotypes at a high level. The expression concentrated in the vascular stria, spiral ligament, basal membrane, tectorial membrane, hair cells, supporting cells and spiral ganglion cells. Expressions in the vascular stria and organ of Corti were stronger comparing to other inner ear structures. Conclusion The Smad4 gene is one of genes existing in the postnatal cochlea extensively. As a signalling factor at downstream of the Bmp4 pathway, the Smad4 gene may play an important role in the process of formation of the osseous otocyst and differentiation of sensory cells." @default.
- W2377747403 created "2016-06-24" @default.
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- W2377747403 date "2006-01-01" @default.
- W2377747403 modified "2023-09-23" @default.
- W2377747403 title "Location and distribution of the Smad4 gene in wild-type and mutant mice" @default.
- W2377747403 hasPublicationYear "2006" @default.
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