Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377751202> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2377751202 abstract "Objective:Transcription factor Snail can restrain the expression of E-cad,which results in epithelial-mesenchymal transition,thereby promoting invasion and metastasis of cancers.This study aimed to investigate the role and significance of EMT regulated by Snail in colorectal cancer of invasion and metastasis,through detecting the expression of Snail and E-cad in colorectal cancer,adjacent tissues and colorectal cancer cells SW480.Methods:Immunohistochemical detection the Snail,E-cad expression of 40 cases of colorectal cancer and adjacent tissues and to analyze their correlation;siRNA interference Snail gene of colorectal cancer cells SW480 which were divided into control group,empty plasmid group and transfection group,RT-PCR were used to detect Snail,E-cad mRNA expression in each group;Transwell chamber invasion assay and heterogeneous matrix adhesion experiments were used to detect the invasion of colorectal cancer cell in each group and the heterogeneity of adhesion ability.Results:The positive rate of Snail and E-cad were 57.5% and 27.5% in colorectal cancer tissues,and 10%,80% in adjacent tissues respectively,with statistically significant between colorectal cancer tissues and adjacent tissues(P0.05).The expression of these two proteins was related to the differentiation and lymph node metastasis(P0.05),but not to patients'age,sex(P 0.05).And the expression of Snail was negatively correlated with E-cad(P 0.05).RT-PCR results showed that compared with the control group,Snail,E-cad mRNA expression in the empty plasmid group was not significant(P0.05),while transfection groups was statistically significant(P0.05);matrix invasion assay and heterogeneous adhesion test results showed that compared with the control group,colorectal cancer cells transfected reduced invasiveness and adhesion heterogeneity,the difference was statistically significance(P0.05),while the empty plasmid group was not statistically significant(P0.05).Conclusion:Snail regulation of EMT was closely related with invasion and metastasis of colorectal cancer,Snail,E-cad can be used as the indicators of invasion and metastasis of colorectal cancer." @default.
- W2377751202 created "2016-06-24" @default.
- W2377751202 creator A5020517993 @default.
- W2377751202 date "2011-01-01" @default.
- W2377751202 modified "2023-09-26" @default.
- W2377751202 title "To investigate the role and significance of EMT regulated by Snail in the invasion and metastasis of colorectal cancer" @default.
- W2377751202 hasPublicationYear "2011" @default.
- W2377751202 type Work @default.
- W2377751202 sameAs 2377751202 @default.
- W2377751202 citedByCount "0" @default.
- W2377751202 crossrefType "journal-article" @default.
- W2377751202 hasAuthorship W2377751202A5020517993 @default.
- W2377751202 hasConcept C104317684 @default.
- W2377751202 hasConcept C119056186 @default.
- W2377751202 hasConcept C121608353 @default.
- W2377751202 hasConcept C126322002 @default.
- W2377751202 hasConcept C143998085 @default.
- W2377751202 hasConcept C18903297 @default.
- W2377751202 hasConcept C203014093 @default.
- W2377751202 hasConcept C204232928 @default.
- W2377751202 hasConcept C2779013556 @default.
- W2377751202 hasConcept C2779965526 @default.
- W2377751202 hasConcept C48023723 @default.
- W2377751202 hasConcept C502942594 @default.
- W2377751202 hasConcept C526805850 @default.
- W2377751202 hasConcept C54009773 @default.
- W2377751202 hasConcept C54355233 @default.
- W2377751202 hasConcept C71924100 @default.
- W2377751202 hasConcept C76419328 @default.
- W2377751202 hasConcept C86803240 @default.
- W2377751202 hasConceptScore W2377751202C104317684 @default.
- W2377751202 hasConceptScore W2377751202C119056186 @default.
- W2377751202 hasConceptScore W2377751202C121608353 @default.
- W2377751202 hasConceptScore W2377751202C126322002 @default.
- W2377751202 hasConceptScore W2377751202C143998085 @default.
- W2377751202 hasConceptScore W2377751202C18903297 @default.
- W2377751202 hasConceptScore W2377751202C203014093 @default.
- W2377751202 hasConceptScore W2377751202C204232928 @default.
- W2377751202 hasConceptScore W2377751202C2779013556 @default.
- W2377751202 hasConceptScore W2377751202C2779965526 @default.
- W2377751202 hasConceptScore W2377751202C48023723 @default.
- W2377751202 hasConceptScore W2377751202C502942594 @default.
- W2377751202 hasConceptScore W2377751202C526805850 @default.
- W2377751202 hasConceptScore W2377751202C54009773 @default.
- W2377751202 hasConceptScore W2377751202C54355233 @default.
- W2377751202 hasConceptScore W2377751202C71924100 @default.
- W2377751202 hasConceptScore W2377751202C76419328 @default.
- W2377751202 hasConceptScore W2377751202C86803240 @default.
- W2377751202 hasLocation W23777512021 @default.
- W2377751202 hasOpenAccess W2377751202 @default.
- W2377751202 hasPrimaryLocation W23777512021 @default.
- W2377751202 hasRelatedWork W1757111527 @default.
- W2377751202 hasRelatedWork W1969004585 @default.
- W2377751202 hasRelatedWork W1994071504 @default.
- W2377751202 hasRelatedWork W2002981032 @default.
- W2377751202 hasRelatedWork W2010872844 @default.
- W2377751202 hasRelatedWork W2097681338 @default.
- W2377751202 hasRelatedWork W2116141371 @default.
- W2377751202 hasRelatedWork W2148981036 @default.
- W2377751202 hasRelatedWork W2239348504 @default.
- W2377751202 hasRelatedWork W2353920132 @default.
- W2377751202 hasRelatedWork W2366155889 @default.
- W2377751202 hasRelatedWork W2379318227 @default.
- W2377751202 hasRelatedWork W2384887927 @default.
- W2377751202 hasRelatedWork W2933433169 @default.
- W2377751202 hasRelatedWork W2952654528 @default.
- W2377751202 hasRelatedWork W3030254079 @default.
- W2377751202 hasRelatedWork W3032644183 @default.
- W2377751202 hasRelatedWork W3032705516 @default.
- W2377751202 hasRelatedWork W3108660287 @default.
- W2377751202 hasRelatedWork W639515081 @default.
- W2377751202 isParatext "false" @default.
- W2377751202 isRetracted "false" @default.
- W2377751202 magId "2377751202" @default.
- W2377751202 workType "article" @default.