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- W2377760027 abstract "Objective To establish a chronic neuropathic pain model by L4/5 spinal nerve ligation in rats.Methods Twenty-six adult male Wistar rats were randomly divided into 3 gmups:Experimental group (n = 10) received ligation of left L4/5 spinal nerve;sham operating group (n = 10) in which left L4/5 spinal nerve were exposed but not ligated and control group (n = 6) received no treatment.The changes of rat behaviour were observed.The pain threshold by electric stimuli and the tail flick latency evoked by nociceptive temperature stimuli were respectively measured from 3 days after operation to 10 weeks,once a week.Results In experimental group,the behaviours of rats were significantly abnormal after operation.The pain threshold by electric stimuli and the tail flick latency evoked by noxious temperature stimuli were significantly decreased as compared to the baseline value before operation and lower than in sham operating and control groups (P 0.05). Conclusion After ligature of L4/5 spinal nerve in rats,persistent and obvious spontaneous pain and evoked pain can be induced. The results suggest the chronic neuropathic pain model is reliable and successful." @default.
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- W2377760027 date "2010-01-01" @default.
- W2377760027 modified "2023-09-25" @default.
- W2377760027 title "Establishment of Chronic Neuropathic Pain Model by L4/5 Spinal Nerve Ligature in Rats" @default.
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