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- W2377762848 abstract "C-terminal EHDs (Eps15 homology-domain-containing proteins) are newly identified key regulators of endosomal membrane trafficking. Here we show that D. discoideum contains a single EHD protein that localizes to endosomal compartments and newly formed phagosomes. We provide the first evidence that EHD regulates phagosome maturation. Deletion of EHD results in defects in intraphagosomal proteolysis and acidification. These defects are linked to early delivery of lysosomal enzymes and fast retrieval of the vacuolar H+-ATPase in maturing phagosomes. We also demonstrate that EHD physically interacts with DymA. Our results indicate that EHD and DymA can associate independently to endomembranes, and yet they share identical kinetics of phagosome recruitment and release during phagosome maturation. Functional analysis of ehd−, dymA−, and double dymA−/ehd− knock-out strains indicate that DymA and EHD play non-redundant and independent functions in phagosome maturation. Finally, we show that the absence of EHD leads to increase tubulation of endosomes, indicating that EHD participates in the scission of endosomal tubules as reported for DymA." @default.
- W2377762848 created "2016-06-24" @default.
- W2377762848 creator A5003320334 @default.
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- W2377762848 date "2016-01-01" @default.
- W2377762848 modified "2023-10-17" @default.
- W2377762848 title "Dictyostelium EHD associates with Dynamin and participates in phagosome maturation" @default.
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- W2377762848 doi "https://doi.org/10.1242/jcs.182857" @default.
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