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- W2377763913 abstract "Objective To investigate the therapeutic effects of retrovirus vector mediated genes transfer of γ interferon (IFN γ) and interleukin 4 (IL 4) in the treatment of C6 glioma.Methods Retrovirus vectors encoding IFN γ or IL 4 gene were transfected into PA317 packaging cells.The intracranial C6 glioma animal model was established in immunocompetent Wistar rats.PA317IFN γ and PA317IL 4 cells were stereotactically implanted into the tumor areas alone or together.The survival of tumor bearing rats was examined,tumor volumes measured and immunohistochemical analyses of CD4 + and CD8 + T lymphocyte infiltration performed.Results Tumor growth was suppressed and the rats bearing glioma survived longer by in situ implanted PA317IFN γ or PA317IL 4 cells.Immunohistochemical analyses revealed that tumor growth arrest was associated with an infiltration of greater number CD4 + and CD8 + T lymphocyte in tumor areas.The therapeutic effects of PA317IFN γ and PA317IL 4 together were better than themselves alone.Conclusion Implantation of retroviral packaging cells containing IL 4 and IFN γ genes into established intracranial gliomas lead to tumor growth arrest that was associated with an infiltration of greater number CD4 + and CD8 + T lymphocyte in tumor areas.The therapeutic effects of PA317IFN γ and PA317IL 4 together were better than themselves alone." @default.
- W2377763913 created "2016-06-24" @default.
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- W2377763913 date "2004-01-01" @default.
- W2377763913 modified "2023-10-12" @default.
- W2377763913 title "Immune gene therapy of glioma by retroviral γ-interferon and interleukin-4 genes transfer" @default.
- W2377763913 hasPublicationYear "2004" @default.
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