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- W2377764150 abstract "In order to generate monoclonal antibody to human stem cell factor receptor(SCF R), we synthesized two peptides according to the protein sequence of SCF R. The peptides were linked with carrier protein and then were used as fusion antigens for immunization. Two peptides SCFR 1 and SCFR 2, which correspond to the carboxyl terminal and extracelular portion of SCF R separately, were designed on the basis of computer assisted analysis of the structural features such as antigenicity and homology etc. After immunization and cell fusion process, we have obtained 7 strains of hybridomas producing monoclonal antibodies to these peptides. These antibodies react specifically wth the synthetic peptides but not the carrier protein and other cytokines. In APAAP test with mAb SB304(to SCFR 1), mild positive staining signals were observed in HEL cell line which expresses SCF R. In addition, SB304 can react with epithelial cells and pigmental cells from fetal skin and stomach mucosa by immunohistochemical identification. These results imply that the SB304 can recognize and bind the natural SCF R protein. The subclasses of the 7 strains mAbs include mice IgG1, IgG2 and IgG2b." @default.
- W2377764150 created "2016-06-24" @default.
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- W2377764150 date "1998-01-01" @default.
- W2377764150 modified "2023-09-24" @default.
- W2377764150 title "Generation of mAbs against synthetic SCF receptor peptides" @default.
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