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- W2377771235 abstract "Objective To investigate the effects of mouse amniotic fluid on the proliferation and apoptosis of mouse hepatoma cell line H22.Methods Treated with the mixture of RPMI 1640 medium and 10% mouse amniotic fluid collected respectively on gestational day 11,13,15 and 17 or RPMI 1640 medium as control,the proliferation of H22 cells was detected with MTT and the apoptosis of H22 cells with Annexin V-FITC;H22 cells were observed morphologically under electron microscope;The expressions of proliferating cell nuclear antigen(PCNA) and p53 in H22 cells were investigated with immunofluorescence staining(S-P method) and laser confocal microscopy.Results Amniotic fluid significantly inhibited the cell proliferation as well as the PCNA expressions,increased the p53 expressions and induced cell apoptosis.The amniotic fluid collected on gestational day 11 was the most effective,while that of gestational day 17 was the least effective(P0.05),and their effects were both in a time-dependent manner.There was a negative correlation between PCNA and p53(r=-0.808,P0.01).Conclusion Amniotic fluid collected on gestational day 11,13,15 and 17 can inhibit the proliferation of H22 cells and induce their apoptosis.The earlier pregnancy and the longer intervention is,more significant effects of amniotic fluid are." @default.
- W2377771235 created "2016-06-24" @default.
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- W2377771235 date "2008-01-01" @default.
- W2377771235 modified "2023-09-23" @default.
- W2377771235 title "Effects of mouse amniotic fluid collected on different gestational days on proliferation and apoptosis of H_(22) cells in vitro" @default.
- W2377771235 hasPublicationYear "2008" @default.
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