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- W2377771801 abstract "To observe the effect of Artesunate on the egg granuloma formation of Schistosoma mansoni, BALB/c mice infected with S.mansoni cercariae by tail-dipping method were administrated orally with Artesunate at different dosages and at different developmental stages of parasites. After 2-6 weeks of treatment, mice were scarified, and the paraffin-embedded sections of liver were stained by hematoxylin-eosin(HE),and underwent the pathological examination. The size of granulomas was measured by using a VM-30 videomicrometer and NIH image software for more than 10 granulomas in each mouse. And the average granuloma area (μm~2) was calculated for each mouse. It was found that most granuloma in liver of mice in the control group consisted of numerous infiltrations with inflammatory cells and mesenchymal fibroblast, while in the treated group of mice, no granuloma formation was observed or the size of granuloma was significantly reduced in comparison with that of the control group. And there were only small amount of infiltrations with inflammatory cells around the granulomas at dosage of 100 mg/kg Artesunate administrated, no significant difference between the treated and control groups was observed, but the average size of egg-granuloma formation was reduced by 36.9%, but at dosages of 300 mg/kg and 500 mg/kg, no egg was found in the pathological sections or the egg-granuloma could be observed . At different developmental stages of parasites, the size of egg-granulomas in liver of untreated group was larger than that of the treated group of mice with significant differences. Also, no egg or egg-granuloma formation could be found in the 21 days or 22 days development of parasites. It is concluded that Artesunate can inhibit the egg-granuloma formation of S.mansoni, decrease the rate of egg production,and reduce the damages in liver induced by the guanuloma formation." @default.
- W2377771801 created "2016-06-24" @default.
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- W2377771801 date "2005-01-01" @default.
- W2377771801 modified "2023-09-25" @default.
- W2377771801 title "Effect of Artesunate on the egg granuloma formation of Schistosoma mansoni" @default.
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