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- W2377771844 abstract "Objective To study expression changes of mitochondrial DNA ATPase 6,8 genes (ATPase 6,8 genes) and mitochondrial function changes in small intestinal epithelia in hemorrhagic shock rats, which may provide molecular biological basis for intestinal target theory and mitochondrial energy metabolism during hemorrhagic shock. Methods A total of 24 Wistar rats were randomly divided into six groups, ie, pre shock group, shock for 1, 2, 3, 4 and 5 hours groups (shock 1,shock 2, shock 3, shock 4 and shock 5 groups respectively). The expressions of mitochondrial ATPase 6,8 genes were observed by means of RT PCR. The mitochondrial parameters of morphometry were examined by electron microscopy and biogenetics stereology, and respiratory function by Clark oxygen electrode. Results The expressions of ATPase 6,8 genes increased in epithelia after hemorrhagic shock for one and two hours and decreased gradually. In the shock 5 group, the expressions reached the lowest, ie, 69.3% and 78.4% of the normal expressions respectively ( P 0.01 and P 0.05). In the shock 2 and 5 groups, mean transaction area, diameter, surface density and volume density of mitochondria increased significantly, which were 2.0, 1.45, 1.47 and 2.22 respectively more than those in the pre shock group ( P 0.01). Meanwhile, specific surface and numeral density of the mitochondria decreased by 32% and 24% respectively ( P 0.01 and P 0.05 respectively). The mitochondrial crist and matrix were destroyed seriously and its respiratory control ratio and efficiency of oxidative phosphorylation dropped markedly compared with that in the pre shock group ( P 0.01). Conclusions Expressions of ATPase 6,8 genes in the small intestinal epithelia decrease at hemorrhagic shock. In the meantime, the mitochondrial respiratory function is affected and there occur changes of the mitochondrial ultrastructure in rats after hemorrhagic shock." @default.
- W2377771844 created "2016-06-24" @default.
- W2377771844 creator A5062310871 @default.
- W2377771844 date "2004-01-01" @default.
- W2377771844 modified "2023-09-25" @default.
- W2377771844 title "Expression changes of mitochondrial DNA adenosinetriphosphatase 6,8 genes and mitochondrial function changes in epithelial cells of small intestine in hemorrhagic shock rats" @default.
- W2377771844 hasPublicationYear "2004" @default.
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