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- W2377777110 abstract "Objective No uniform standards has been established for the clinical diagnosis of schizophrenia. The article was to investigate the differentially expressed microRNA( miRNA) profile and explore its clinical significance. Methods Differentially expressed miRNAs were screened by Flash TagTMBiotin RNA chips and SAM software in serum of patients with schizophrenia and healthy controls,then the validation was performed by real-time fluorescent quantitative reverse transcription polymerase chain reaction( RT-PCR). Results Three differentially expressed miRNAs were screened,including up-regulated hsa-miR-1281( fold change =1. 508 81) and two down-regulated miRNAs: hsa-miR-2861( fold change = 0. 642) and hsa-miR-638( fold change = 0. 516). The comparative analysis of RT-PCR by SPSS 17. 0 Kruskal Wallis H Test validated the expression levels of hsa-miR-2861 and hsa-miR-638 in patients with schizophrenia decreased significantly in comparison to healthy controls( χ2= 4. 089,χ2= 4. 083,P 0. 001). While the expression level of hsa-miR-1281 in patients with schizophrenia was in higher expression level compared with control group( χ2=5. 333,P 0. 001). Conclusion There are differentially expressed miRNA profile in serum of patients with schizophrenia,in which miR-1281,miR-2861 and miR-638 could be new serum markers for diagnosis of schizophrenia." @default.
- W2377777110 created "2016-06-24" @default.
- W2377777110 creator A5036846763 @default.
- W2377777110 date "2014-01-01" @default.
- W2377777110 modified "2023-09-23" @default.
- W2377777110 title "Detection of differentially expressed microRNA profile in serum of patients with schizophrenia" @default.
- W2377777110 hasPublicationYear "2014" @default.
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