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- W2377778864 abstract "Objective To approach the effects of verapamil on carmustine(BCNU) chemotherapy to U251 glioma in mice. Methods The U251 glioma athymic mouse models were made,and then treated with BCNU and verapamil + BCNU respectively. Expression of multidrug resistance 1(MDR1,P-gp) ,multidrug resistance protein 1(MRP1) ,and lung resistance-related protein(LRP) were determined by immunofluorescence staining. Results Compared with BCNU group,the tumors reduced significantly in verapamil + BCNU group,especially in the first to forth weeks(P 0.05) . The expression of P-gp,MRP1,and LRP were positive in U251 glioma cells,and had no changes in morphology. Conclusion Verapamil can increase U251 glioma cells' chemosensitive to BCNU,and reverse multidrug resistance." @default.
- W2377778864 created "2016-06-24" @default.
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- W2377778864 date "2010-01-01" @default.
- W2377778864 modified "2023-09-26" @default.
- W2377778864 title "Effects of Verapamil on Carmustine Chemotherapy to U251 Glioma in Mice" @default.
- W2377778864 hasPublicationYear "2010" @default.
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