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- W2377778893 abstract "Objective To study the expression and activation of IL-6,signal transducers and activators of transcription 3(STAT3)in airway of asthmatic mouse model and its association with airway inflammation.Methods Thirty Balb/c mice were randomly divided into control group(n = 10),asthma group(n = 10)and AG490 group(n = 10).The mice were sensitized with ovalbumin to establish the asthmatic model.The histological changes were evaluated by hematoxylin and eosin staining,bronchoalveolar lavage fluid(BALF)were collected,the total cell and the cell differentials were counted,the levels of IL-4,IL-5 and IL-6 in BALF were measured by enzyme-linked immunosorbent assay.The expression of STAT3 in airway were detected by immunohistochemistry technique;lung tissue extracts were analyzed for total STAT3 and p-STAT3 by Western blot.SPSS13.0 software was used to analyze the data.Results Typical inflammatory changes were shown in asthma group compared with AG490 group.The total cells,EOS amounts and levels of cytokine in BALF of asthma groups were significantly higher than in those in AG490 group(P 0.05).The expression of STAT3 and p-STAT3 in asthma group were significantly higher than that in control group(P 0.05),The level of p-STAT3 in AG490 group were significantly lower than that in asthma group(P 0.05).The level of STAT3 in airway and level of p-STAT3 in lung tissue had positive correlations with IL-4,IL-5 and IL-6 in BALF(P 0.05).Conclusions The expression and activation of STAT3 in airway were up-regulated in asthmatic mouse model,its level was associated with Th2-biased airway inflammation and increment of IL-6 in airway,IL-6/STAT3 signaling pathway may play an important role in airway inflammation." @default.
- W2377778893 created "2016-06-24" @default.
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- W2377778893 date "2011-01-01" @default.
- W2377778893 modified "2023-09-23" @default.
- W2377778893 title "Expression and activation of IL-6,STAT3 in airway of asthmatic mouse model and its relationship with airway inflammation" @default.
- W2377778893 hasPublicationYear "2011" @default.
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