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- W2377779008 abstract "Objective To investigate the effects of local administration of Alendronate on orthodontic tooth movement and periodontal ligament in wistar rats.Methods The left upper first molars of 32 7-week-old male wistar rats were moved mesially with coil spring.Alendronate solution at the concentration of 0.02 mmol/L,0.1 mmol/L,0.5 mmol/L was injected into the palatal submucosal area adjacent to the left upper first molar in experimental group every 3 days during the experimental period.The same amount of 0.9% NaCl solution was injected into the same area in control group.The distance of tooth movement was measured on the 0,1,3,7,10,14,17,21day.The rats were sacrificed on the 21st day.Sections were stained and then observed with microscope.Results 1.The distance of tooth movement in the experimental group was significantly smaller than that in the control group.2.The number of osteoclasts and cementoclasts on the pressure side in the experiment group was significantly smaller than that in the control group through the experimental period.Conclusions The localized use of Alendronate may be a useful agent for anchorage control and could be a beneficial therapeutic adjunct for orthodontic treatment." @default.
- W2377779008 created "2016-06-24" @default.
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- W2377779008 date "2009-01-01" @default.
- W2377779008 modified "2023-09-23" @default.
- W2377779008 title "Effects of local administration of Alendronate on orthodontic tooth movement and periodontal ligament in rats" @default.
- W2377779008 hasPublicationYear "2009" @default.
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