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- W2377786883 abstract "Objective To evaluate the effect of ulinastatin on pulmonary endothelial permeability via pulseindicated continuous cardiac output (PiCCO) in patients with acute respiration distress syndrome (ARDS). Methods Fifty -four patients with ARDS were divided into mechanical ventilation group (control group) and mechanical ventilation combined ulinastatin group (ulinastatin group). The extra-vascular lung water index (EVLWI), pulmonary vascular permeability index(PVPI), acute physiology and chronic health evaluation (APACHE Ⅱ) and sepsis-related organ failure assessment (SOFA) score were recorded.The duration of ventilation, length of stay in ICU and case fatalities of two groups also assessed. Results The EVLWI, PaO2/FiO2 and APACHEⅡ score at the 3rd , 7th day in ulinastatin group were significantly lower than the control group (t=2.27,2.86,3.91,5.34,2.52, 3.23,P0.05); the same result was observed in PVPI and SOFA scores at the 7th day (t=5.02,2.25,P0.05). After therapy, the duration of ventilation and length of stay in ICU in ulinastatin group was significantly shorter than the control group (t = 3.39,3.58,P 0.05).The mortality of 28 days of two groups were not distinct (χ2 =0.38,P 0.05). Conclusions Ulinastatin treatment improved hypoxemia, elevated pulmonary endothelial permeability, reduced duration of ventilation and length of stay in ICU in patients with ARDS." @default.
- W2377786883 created "2016-06-24" @default.
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- W2377786883 date "2009-01-01" @default.
- W2377786883 modified "2023-09-28" @default.
- W2377786883 title "Effects of ulinastrtin on pulmonary endothelial permeability in patients with ARDS" @default.
- W2377786883 hasPublicationYear "2009" @default.
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