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- W2377794310 abstract "OBJECTIVE:To illustrate the relationship between X-linked inhibitor of apoptosis protein(XIAP) and the clinical factors and prognosis of osteosarcoma.METHODS:The expression of XIAP in oteosarcoma or normal bone tissues which adjacent to osteosarcoma was detected by immunohistochemmistry.The related expression level of XIAP and clinical variables were calculated by Chi-square test.Kaplan-meier method was used to calculate the overall survival rate.RESULTS:The expression of XIAP was observed in cytoplasm.It was expressed both in osteosarcoma and normal bone tissues,but there was significant difference between the two groups(P = 0.012).The positive expression rate of XIAP was 74% in osteosarcoma tissues while only 25% in normal bone tissues.No correlations were found between the expression of XIAP and the gender,age,size or location of tumor as well as clinical stage(P = 0.009).Kaplan-meier analysis showed that in 40 cases of stage ⅡB patients,the disease free survival time in XIAP-over-expression patients was lower than that in low-expression patients(P = 0.023),and in 50 patients(40 cases of stage ⅡB and 10 cases of stage Ⅲ),the overall survival time in XIAP-over-expression patients was also lower than that in low-expression patients(P = 0.004).CONCLUSION:XIAP is correlated with the prognosis of patients with osteosarcoma." @default.
- W2377794310 created "2016-06-24" @default.
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- W2377794310 date "2013-01-01" @default.
- W2377794310 modified "2023-09-23" @default.
- W2377794310 title "Expression of XIAP in osteosarcoma tissues and its clinical significance" @default.
- W2377794310 hasPublicationYear "2013" @default.
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