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- W2377832057 abstract "Objective:To study the effects of the matrix metalloproteinase-9(MMP-9) and tissue inhibitors of metalloproteinases 1(TIMP1) in cerebral tissues of newborn rats after brain ischemia injury.Methods:Seventy-five,seven-day-old rats were classified into three groups randomly:normal control group(n= 25),hypoxia-ischemia group(25),and sham operation group(25).The rats in the hypoxia-ischemia group were subjected to right carotid artery occusion,and the cerebral MMP-9 and TIMP1 levels were detected by immuno-histochemistry method 24 hours later.Results:MMP-9 and TIMP1 were expressed in the three groups,but there were significant differences among the three groups.The cerebral MMP-9 and TIMP1 levels were increased in the hypoxia-ischemia group compared with those in the normal control and sham operation group(P0.01),and the cerebral MMP-9 level showed positive correlation with TIMP1 level in the hypoxia-ischemia group(P0.01),whereas no correlation was founded in the normal control or the sham operation group(P0.05).Conclusion:The expression of MMP-9 and TIMP1 is increased in newborn ischemic brain and may contribute to the brain injury after ischemia condition." @default.
- W2377832057 created "2016-06-24" @default.
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- W2377832057 date "2012-01-01" @default.
- W2377832057 modified "2023-09-23" @default.
- W2377832057 title "Expression and significance of MMP-9 and TIMP1 in newborn rat brain after ischemia injury" @default.
- W2377832057 hasPublicationYear "2012" @default.
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