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- W2377867274 abstract "Objective:To study the effect of Yiqi Ruanjian Sanjie method on myocardial TRα1mRNA expression of Wistar rats with hypothyroidism.Methods:Wistar rats were divided into 4 groups:normal group,model group,L-T4 group,and Yiqi Ruanjian Sanjie method.Each group had 30 rats.Normal group:ordinary diet and double distilled water(DDW)were fed while model control group was fed with low iodine diet(LD)and DDW.Serum thyroid-stimulating hormone(TSH)was measured with Elisa.Serum total levels of T4(TT4)and T3(TT3)were measured with radioimmunoassay(RIA).Myocardial TRα1mRNA expression was measured with real-time quantity PCR.Ger-Arsenic cerium spectrophotometry was used to measure median urinary iodine(MUI).Myocardial morphological changes were observed under optical microscope,and myocardial electrocardio was measured by ECG machine.Results:Giving the processing factor 56 days later,serum TT3 values in L-T4 group and Yiqi Ruanjian Sanjie group were higher than that in normal group and model group(P 0.01).Serum TT4 value was higher(P 0.001).Serum TSH value was lower(P 0.01,and Yiqi Ruanjian Sanjie group was obviously lower than L-T4 group).ECG indicated differnece between L-T4 group and Yiqi Ruanjian Sanjie group(P 0.05),and heart rate and low-volume were recovered.Yiqi Ruanjian Sanjie group of myocardial TRα1mRNA expression was 1.08 times higher than L-T4 group.Myocardial morphology of Yiqi Ruanjian Sanjie group was recovered obviously more than L-T4 group.Conclusion:Compared with L-T4 group,Yiqi Ruanjian Sanjie method can make myocardic of hypothyroidism recovery by myocardial TRα1mRNA." @default.
- W2377867274 created "2016-06-24" @default.
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- W2377867274 date "2012-01-01" @default.
- W2377867274 modified "2023-09-23" @default.
- W2377867274 title "Effect of Yiqi Ruanjian Sanjie Method on Myocardial Trα1mRNA Expression of Wistar rats with Hypothyroidism" @default.
- W2377867274 hasPublicationYear "2012" @default.
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