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- W2377876123 abstract "Objective To study the cerebral protection of topiramate after acute ischemia and reperfusion. Methods 25 hypertension model Rats which were made by bilateral renal artery stenosis surgery were fed for two months. The hypertensive rats were devided randomly into 3 groups: topiramate group 9 rats, ischemic group 9 rats and sham operation group 7 rats(eontrol group) . All rats were performed middle cerebral artery occlusion (MCAO) operations except for those of the control group. The reperfusion time was 2 hours. The rat brains were obtained by quickly decapitated 6h after reperfusion and stained with TTC. Then the infarct and total volume of rat brains were measured and calculated with computerized pathological image analyzer. The ratio of infarct volume was obtained afterwards. Results The ratio of infarct volume of topiramate group was 0. 108 7±0. 042 6 which was much smaller than that of ischemic reperfusion group 0. 286 3±0. 064 7 ( P 0. 05). No infarct area had been found in rat brains of control group. Conclusion Topiramate can decrease the infarct volume and may therefore have protective effect upon the ischemic cerebral tissue after MCAO and reperfusion." @default.
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- W2377876123 date "2004-01-01" @default.
- W2377876123 modified "2023-09-23" @default.
- W2377876123 title "Study of the brain protective effect of topiramate after acute ischemia and reperfusion injury" @default.
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