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- W2377881604 abstract "Objective Using three-dimensional magnetic resonance imaging to assess volumetric abnormalities of grey matter in chronic ketamine dependent subjects.Methods We used voxel based morphometry in conjunction with statistical parametric mapping on the structural magnetic resonance images of ketamine-dependent(n=41) and drug-naive control individuals(n=44) to assess differences between the two groups in gray matter volume.Results We found a decrease in gray matter volume in bilateral frontal(left superior frontal and right middle frontal) cortex of ketamine patients in comparison to controls(P0.05 corrected for multiple comparisons at cluster-level).Also,we found that the duration(months) of ketamine use was negatively correlated with gray matter volume in bilateral frontal cortex while the estimated total lifetime ketamine consumption was only negatively correlated with gray matter volume in left superior frontal cortex.Conclusions This is the first voxel-based morphometry study showing reduction of frontal gray matter volume in patients with ketamine dependence and showing the correlation of duration of ketamine use and cumulative doses of ketamine with decrease of frontal gray matter volume.Brain structural study of the affected areas in patients with ketamine dependence might better guide future research into the poorly understood condition of ketamine addiction and its correlates of schizophrenia." @default.
- W2377881604 created "2016-06-24" @default.
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- W2377881604 date "2012-01-01" @default.
- W2377881604 modified "2023-09-24" @default.
- W2377881604 title "Volumetric abnormalities of gray matter in ketamine dependent patients:a voxel based morphometry study" @default.
- W2377881604 hasPublicationYear "2012" @default.
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