Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377882963> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2377882963 abstract "OBJECTIVE:A chromosomal aberration(CA) screening test was established using eight-well chamber slides without adopting complicated procedures and chemical agents in the traditional chromosomal aberration test in vitro.The validation of the protocol was conducted using several genotoxic chemicals with various mechanisms of action and non-genotoxic compounds.METHODS:Optimized conditions for the test procedure in which cells were treated with cyclophosphamide(CP) for 6 h(for the +S_9 condition) and mitomycin C(MMC) for 24 h(for the -S_9 condition) were investigated.And then five known genotoxic chemicals including benzo(a)pyrene[B(a)P],2-aminoanthracene(2- AA),methyl methanesulphonate(MMS),ethyl methansulfonate(EMS),etoposide(Eto) and two non-genotoxic chemicals including ampicilin sodium salt(AS) and sodium chloride(SC) were used in the sensitive and specific validation research under these conditions.RESULTS:The CA percentage of CP(6 h,+S_9) and MMC(24 h,-S_9) showed dose-dependent accumulation.In the validation tests,B(a)P and 2-AA were positive only in(6 h,+S_9) condition while MMS,EMS and Eto showed positive results in both +/-S_9 conditions.AS and SC were negative in both +/-S_9 conditions.CONCLUSION: The chromosomal aberration test using eight-well chamber slides could be considered as a simple,rapid and effective method,which could be used in genotoxicity screening in the early research phase of drug development." @default.
- W2377882963 created "2016-06-24" @default.
- W2377882963 creator A5034609211 @default.
- W2377882963 date "2011-01-01" @default.
- W2377882963 modified "2023-09-23" @default.
- W2377882963 title "Establishment and validation of a chromosomal aberration screening test using eight-well chamber slides" @default.
- W2377882963 hasPublicationYear "2011" @default.
- W2377882963 type Work @default.
- W2377882963 sameAs 2377882963 @default.
- W2377882963 citedByCount "0" @default.
- W2377882963 crossrefType "journal-article" @default.
- W2377882963 hasAuthorship W2377882963A5034609211 @default.
- W2377882963 hasConcept C104317684 @default.
- W2377882963 hasConcept C114246631 @default.
- W2377882963 hasConcept C141071460 @default.
- W2377882963 hasConcept C178790620 @default.
- W2377882963 hasConcept C185592680 @default.
- W2377882963 hasConcept C2776639595 @default.
- W2377882963 hasConcept C2778951431 @default.
- W2377882963 hasConcept C2778959862 @default.
- W2377882963 hasConcept C2779338040 @default.
- W2377882963 hasConcept C29730261 @default.
- W2377882963 hasConcept C2994296024 @default.
- W2377882963 hasConcept C30481170 @default.
- W2377882963 hasConcept C43617362 @default.
- W2377882963 hasConcept C45080847 @default.
- W2377882963 hasConcept C55493867 @default.
- W2377882963 hasConcept C71924100 @default.
- W2377882963 hasConceptScore W2377882963C104317684 @default.
- W2377882963 hasConceptScore W2377882963C114246631 @default.
- W2377882963 hasConceptScore W2377882963C141071460 @default.
- W2377882963 hasConceptScore W2377882963C178790620 @default.
- W2377882963 hasConceptScore W2377882963C185592680 @default.
- W2377882963 hasConceptScore W2377882963C2776639595 @default.
- W2377882963 hasConceptScore W2377882963C2778951431 @default.
- W2377882963 hasConceptScore W2377882963C2778959862 @default.
- W2377882963 hasConceptScore W2377882963C2779338040 @default.
- W2377882963 hasConceptScore W2377882963C29730261 @default.
- W2377882963 hasConceptScore W2377882963C2994296024 @default.
- W2377882963 hasConceptScore W2377882963C30481170 @default.
- W2377882963 hasConceptScore W2377882963C43617362 @default.
- W2377882963 hasConceptScore W2377882963C45080847 @default.
- W2377882963 hasConceptScore W2377882963C55493867 @default.
- W2377882963 hasConceptScore W2377882963C71924100 @default.
- W2377882963 hasLocation W23778829631 @default.
- W2377882963 hasOpenAccess W2377882963 @default.
- W2377882963 hasPrimaryLocation W23778829631 @default.
- W2377882963 hasRelatedWork W2010056083 @default.
- W2377882963 hasRelatedWork W2028627808 @default.
- W2377882963 hasRelatedWork W2032011324 @default.
- W2377882963 hasRelatedWork W2045009244 @default.
- W2377882963 hasRelatedWork W2061800675 @default.
- W2377882963 hasRelatedWork W2376354374 @default.
- W2377882963 hasRelatedWork W2468996879 @default.
- W2377882963 hasRelatedWork W2891390522 @default.
- W2377882963 hasRelatedWork W1995400227 @default.
- W2377882963 hasRelatedWork W2186295568 @default.
- W2377882963 isParatext "false" @default.
- W2377882963 isRetracted "false" @default.
- W2377882963 magId "2377882963" @default.
- W2377882963 workType "article" @default.