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- W2377883514 abstract "Objective To observe the effect of insulin-lik e growth factor-1o n motor function o f lower limbs and motor evoked potent ial(MEP)after chronic s pinal cord compression in rat.Methods 50Wistar rats were randomly divided int o normal group ,chronic compress ive group,decompressive group,NS grou p and IGF-1group.The animal model of chronic spinal cord compression was establishe d in all groups except for normal group.Compressiv e degree was achieved about 60%in two months.At the time ,decompression w as done in decompressive gro up,NS group and IGF-1group.NS or IGF-1were respectively supplied th rough subarachnoid cavity 1,3,5,7,9d after decompression in NS group and IGF-1group.Motor functio n of lower limbs and motor evoked pote ntial(MEP)were detected 2,4,6,8,10d after decompression.Results Motor function of l ower limbs and amp litude of motor evoked potential(MEP)reduced and delitescen ce of MEP prolonged in chronic compressive group.They obviously r ecovered in I GF-1group(P0.05),and the recovery in IGF-1group was b etter than in decompressive group and NS group(P0.05).Conclusions IGF-1can accele rate undee reversio n of MEP and promote motor function re covery of spinal cord after chronic compressive spin al cord injury." @default.
- W2377883514 created "2016-06-24" @default.
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- W2377883514 date "2002-01-01" @default.
- W2377883514 modified "2023-09-27" @default.
- W2377883514 title "Effect of IGF-1 on motor function of lower limbs and motor evoked potential after chro nic spinal cord compression in rat" @default.
- W2377883514 hasPublicationYear "2002" @default.
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