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- W2377883986 abstract "Objective To explore the protective effects of schisandrin B(Sch-B) treatment on silica-induced lung injury.Methods Sixty four Wistar rats were randomly divided into control group,silica group,and Sch-B treated group.Silicotic animal models received an intratracheal injection of silica.From the second day of model establishment,rats in Sch-B treated group were treated with Sch-B 80 mg/kg/d,ig,once daily.After been treated with Sch-B for 3,7,14 and 21days,4 contrrol rats,6 silica rats and 6 Sch-B treated rats were sacrificed,and lungs were collected.The lung index and histopathological changed in the lungs were observed;the content of HYP(hydroxyproline),MDA(malondialdehyde)and GSH(glutathione)in the lung homogenate were assayed also by a spectrophotometer.Results Compared with silica group,Sch-B significantly alleviated the lung index increase and ameliorated of lung tissue histological damage,inhibited the HYP level,decreased MDA production,and increased the GSH level in the lung homogenate(0.05 or P0.01).Conclusions Sch-B could increase the ability of antioxygen,and provid protective effects against silica-induced ling injury." @default.
- W2377883986 created "2016-06-24" @default.
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- W2377883986 date "2009-01-01" @default.
- W2377883986 modified "2023-09-23" @default.
- W2377883986 title "Protection of Schisandrin B against Silica-induced Lung Injury in Rats" @default.
- W2377883986 hasPublicationYear "2009" @default.
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