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- W2377884958 abstract "Objective To evaluate the role of simvastatin in rats exposed to chronic hypoxic hypercapnia.Methods The pulmonary hypertension rat model was reproduced by chronic hypoxic hypercapnia exposure.Thirty rats were randomly divided into three groups:normal control(NC),hypoxic hypercapnia 4-week(4WH),the intervention effects of simvastatin 4-week(Sim),realtime reverse transcription-polymerase chain reaction was performed to observe the dynamic expression of bFGF mRNA and NF-κB mRNA in the left lung of rats every group.The levels of VEGF in the right lung tissue and the levels of IL-6 in the blood-serum were measured by ELISA.Results Mean pulmonary arterial pressure,weight ratio of RV to LV+S,the leves of VEGF in the right lung tissue and the levels of IL-6 in the blood-serum of group 4WH were significantly higher than that of rats in NC and Sim(P0.01).Electron microscopy showed proliferation of smooth muscle cells and collagenous fibers of pulmonary arterioles in rats of group 4WH,but Simvastatin could reverse the changes mentioned above.bFGF mRNA and NF-κB mRNA of rats in 4WH were significantly higher than those of rats in NC and Sim(P0.05)and the leves of VEGF and IL-6 of rats in 4WH were higher than those of rats in NC and Sim(P0.01).Conclusions Simvastatin can prevent hypoxia pulmonary hypertension by inhibiting to express the albumen of bFGF mRNA,by upregulating NF-κB mRNA,and by inhibiting VEGF,IL-6." @default.
- W2377884958 created "2016-06-24" @default.
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- W2377884958 date "2011-01-01" @default.
- W2377884958 modified "2023-09-27" @default.
- W2377884958 title "Role of simvastatin in rats exposed to chronic hypoxic hypercapnia" @default.
- W2377884958 hasPublicationYear "2011" @default.
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