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- W2377885720 abstract "Objective:To elucidate the influence in the subpopulations of T lymphocyte administrated Hus in mice.Methods:Adopt 10% xanthine i.p. in mice to duplicate hyperuricemia model,and administrate drugs for 6 days beforehand. Then, to detect serum urate concentration by uricase chromatometry, and to measure the percentage of CD_3+、CD_4+、CD_8+and CD_4+/CD_8+ ratio of spleen T lymphocytes by monochromic flow cytometry (FCM).Results:5%,2.5%,1.25% Hus group and allopurinol group had significant differentiation respectively compared with model group (P0.01,n=8), and were lower than the model group, respectively.And 5%,2.5% Hus group had significant differentiation respectively compared with allopurinol group. It denoted that different dosage Hus can respectively reduce serum urine content in hyperuricemia of mice as similar as allopurinol, and even be lower than normal level. In contrast, there were no significant differences between allopurinol group, model group and normal group in the percentage of CD_3+、CD_4+、CD_8+ cells and CD_4+/CD_8+ ratio in spleen lymphocytes,nor were there significant differences between normal group ,model group, allopurinol group and 5% Hus group in the percentage of CD_3+、CD_4+、CD_8+ cells or CD_4+/CD_8+ ratio of spleen lymphocytes. Conclusion:Hus can obviously significant influence in spleen T lymphocyte subpopulations" @default.
- W2377885720 created "2016-06-24" @default.
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- W2377885720 date "2005-01-01" @default.
- W2377885720 modified "2023-09-25" @default.
- W2377885720 title "Influence in the Subpopulations of T Lymphocytes Administrated Hus in Mice" @default.
- W2377885720 hasPublicationYear "2005" @default.
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