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- W2377886071 abstract "ObjectivesTo study the effect of lidocaine hydrochloride on the regional cerebral blood flow (r-CBF) of the injured and the normal cerebral hemisphere in rats with acute local contusion.MethodsRat models with acute local contusion created by Feeney were used.The rats were then treated with 0.2% lidocaine hydrochloride.The r-CBF was continuously measured in both of the injured and the normal cerebral hemisphere.Control group was also treated with 0.2% lidocaine hydrochloride and the r-CBF was studied.ResultsLidocaine reduced the r-CBF of normal brain from 35.71 ml/100 g.min -1 to 30.93 ml/100 g.min -1( P 0.05),but remarkably increased that of injured cerebral hemisphere as compared with untreated control group ( P 0.01).ConclusionLidocaine prevented the reduction of the r-CBF in contused cerebral hemisphere and improved local cerebral circulation." @default.
- W2377886071 created "2016-06-24" @default.
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- W2377886071 date "2004-01-01" @default.
- W2377886071 modified "2023-09-24" @default.
- W2377886071 title "Effect of lidocaine on regional cerebral blood flow in rats with acute local contusion" @default.
- W2377886071 hasPublicationYear "2004" @default.
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