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- W2377887467 abstract "Objective:To establish the model of pulmonary hypertension in rat reflecting of inflammatory effects. Methods:Hypoxia of 10% oxygen concentration for 8 hours 1 day and intravenous injection of ferric chloride (0 6%, 0 2 ml/100g BW) 2 times 1 week were given to the rats for 2, 4 weeks. Results:Raised PAPm and right venticular hypertrophy were found, severe pulmonary arterial vascularization, circulating endothelial cells peeling off and inflammatory cell infiltration in the lung tissue were observed after 2,4 weeks of hypoxia with intravenous injection of ferric chloride (0 6%). Conclusion:The model of pulmonary hypertension by hypoxia and intravenous injection of ferric chloride can be used to study the roles of inflammation playing in the pathogenesis of pulmonary hypertension." @default.
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- W2377887467 date "2000-01-01" @default.
- W2377887467 modified "2023-09-25" @default.
- W2377887467 title "Reproduction of pulmonary hypertension model in rat with hypoxia and ferric chloride" @default.
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