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- W2377887566 abstract "Objective To establish a murine model of invasive pulmonary aspergillosis and to analyze its reserch value. Methods Mice were immunosuppressed with cyclosphosphamide by intraperitoneal injections and blood sample were monitored. Invasive pulmonary aspergillosis was induced by inoculation of Aspergillus fumigatus spore suspension with self-made tracheal intubation. Mice were sacrificed on day 1 、3、5、7 after inoculation and their lung tissues were was cultured and histopathologically analyzed. Results Mice shows a loss of weight and depression after a series of different dose of cyclosphosphamide injection. Routine blood test shows a significant decrease of white blood cells . Nutrogranulocytes and lymphocytes can′t be distinguished. By observing pathological slices, we can see lung tissue lesion aggrates gradually after inoculation. Haemorrhage and cellulose exsudation is obviously seen ; sporus aggregat and germinate. As a result, alveoli are destroyed diffusely and a large area of lung edema happened. Conclusions A murine model of invasive pulmonary aspergillosis is succes sfully established , which will de a reference of further studies of aspergillosis pathogenesis and pathophysiology, in addition to antifungal agent pharmacodynamics." @default.
- W2377887566 created "2016-06-24" @default.
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- W2377887566 date "2011-01-01" @default.
- W2377887566 modified "2023-09-28" @default.
- W2377887566 title "Establishment and analysis of murine model of invasive pulmonary aspergillosis" @default.
- W2377887566 hasPublicationYear "2011" @default.
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