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- W2377887611 abstract "Objective To investigate the effects of SPRIDA,an alkaloid derivative from Sophora alopecuoride,on gene expression profile in mice bearing H22 liver cancer and explore the potential mechanism for its action against liver cancers.Methods The mouse cDNA microarray containing 4096 genes were used to detect the gene expression profile induced by SPRIDA in mice bearing H22 liver cancer,while the gene ontology clustering and statistic analysis of differential expression genes were performed.Results Before and after treatment with SPRIDA,the mice bearing H22 liver cancer showed 358 genes with differential expression.Eighty-three genes showed more than three times,and 275 showed two times as much in expression difference.Gene ontology analysis showed that most of differential expres-sions involved genes related with cell cycling,apoptosis,metabolism,immune response and DNA repair.Conclusion SPRIDA may inhibit tumor growth and metastasis through modulation of gene expressions related with cell cycling,metabolism,immune response and apoptosis." @default.
- W2377887611 created "2016-06-24" @default.
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- W2377887611 date "2009-01-01" @default.
- W2377887611 modified "2023-09-23" @default.
- W2377887611 title "Effect of SPRIDA on gene expression profiles in mice bearing H22 liver cancer" @default.
- W2377887611 hasPublicationYear "2009" @default.
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