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- W2377892254 abstract "Objective To study the changes of pharmacokinetics of the effective fractions of Qingnaoxuanqiao Formula,including geniposide,ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in rats of normal,acute phase and convalescent phase of apoplexy.Methods The model of convalescent phase of apoplexy was established by ligating bilateral carotids of SD rats and feeding for 2 weeks,and the model of acute phase of apoplexy was established by MCAO method.The models were given orally the effective fractions of Qingnaoxuanqiao Formula and the blood samples were extracted by C18 solid phase column.Sec-o-glucosyl-hamaudol was taken as internal index.Agilent Eclipse XDB-C18 chromatography column(4.6 mm×250 mm,5 μm)was applied.The gradient mobile phase was HCN-H2O system with column temperature of 30 ℃ and flow rate was 1.0 mL/min.The detecting wavelength was 203 nm.The plasma concentrations of different effective infractions were analyzed by DAS 1.0 software.Results The pharmacokinetics of geniposide,ginsenoside Rg1,notoginsenoside R1 were fitted with two-compartment model,and that of ginsenoside Rb1 was fitted with one-compartment model in rats.The values of Cmax and AUC of above 4 infractions showed as follows:the value of acute phase groupthat of convalescent phase groupthat of normal group.Conclusion The absorptions of effective fractions of Qingnaoxuanqiao formula in different rat models are different.The value of bioavailability in the same dose is as follow order:the value of acute phase groupthat of convalescent phase groupthat of normal group." @default.
- W2377892254 created "2016-06-24" @default.
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- W2377892254 date "2008-01-01" @default.
- W2377892254 modified "2023-09-25" @default.
- W2377892254 title "Pharmacokinetics of effective fractions of Qingnaoxuanqiao Formula in different rat models" @default.
- W2377892254 hasPublicationYear "2008" @default.
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