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- W2377894610 abstract "Objective:To optimize formulation of Jiangjiao gels and investigate its in vitro percutaneons penetration.Method:Taking cumulative permeation amount per unit area in 24 h of capsaicin as index,effect of dosages of glycerol,propylene glycol and azone on formulation process of capsaicin was investigated by orthogonal test;With isolated rat skin as transdermal barrier,Franz diffusion cell was used as in vitro percutaneous release model,then in vitro transdermal permeability of capsaicin was investigated.The content of capsaicin was determined by HPLC,chromatographic conditions were as follows:Diamonsil C 18 column(4.6 mm × 250 mm,5 μm),mobile phase of methanol-0.1% phosphoric acid solution(65∶ 35),flow rate 1.0 mL·min- 1,detection wavelength 280 nm,column temperature 40 ℃,injection volume 20 μL.Result:Optimal formulation of Jiangjiao gels was 2% carbomer,10% glycerol,20% propylene glycol and 1% azone;In vitro transdermal permeation of capsaicin in Jiangjiao gels fitted zero order kinetics equation,percutaneous permeation rate was 0.353 μg·h- 1·cm- 2.Conclusion:Optimized formulation was reasonable and suitable for topical skin." @default.
- W2377894610 created "2016-06-24" @default.
- W2377894610 creator A5013782324 @default.
- W2377894610 date "2013-01-01" @default.
- W2377894610 modified "2023-09-24" @default.
- W2377894610 title "Optimization of Formulation Process for Jiangjiao Gels by Orthogonal Test" @default.
- W2377894610 hasPublicationYear "2013" @default.
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