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- W2377923166 abstract "Objective: To observe the effect of controlled ovarian hyperstimulation(COH) on mice embryo implantation and the regulatory effect of Bangdeyun,a traditional Chinese medical herbs.Methods: Following the clinical method,mice were injected with 10 IU HCG 48 h after intraperitoneal injection of 10 IU PMSG,the implantation rate and average number of implanted blastocysts were compared among normal pregnancy group,controlled ovarian hyperstimulation group,and Chinese Herbs treated group on pregnancy day 8.The vasopermeability,deciduation and matrix metalloproteinase-9(MMP-9) expression in endometrium were observed under microscope by Evans blue dying,HE stain,and immunohistochemical method respectively on pregnancy day 5.Results: Compared with that respectively in normal group,COH reduced the implantation rate obviously(P0.05),but Bangdeyun improved implantation rate greatly(P0.05).COH inhibited the vasopermeability of endometrium,delayed the endometrium deciduation and inhibited the expression of MMP9,but Bangdeyun can improve the vasopermeability of endometrium,endometrium decidualization and expression of MMP-9.Conclusion: Controlled ovarian hyperstimulation could cause embryo implantation dysfunction through inhibiting the vasopermeability of endometrium,delaying the endometrium decidualization,and inhibiting matix dissolving,but Bangdeyun can improve these changes and help in implantation." @default.
- W2377923166 created "2016-06-24" @default.
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- W2377923166 date "2012-01-01" @default.
- W2377923166 modified "2023-09-25" @default.
- W2377923166 title "Effect of Controlled Ovarian Hyperstimulation on Mice Embryo Implantation and the Regulatory Effect of Traditional Chinese Medicine Bangdeyun" @default.
- W2377923166 hasPublicationYear "2012" @default.
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