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- W2377937117 abstract "Objective: To modify the method to generate middle cerebral artery occlusion(MCAO) model in mice.Methods: Fifty C57BL/6J mice were randomly divided into sham group(n=10) and MCAO group(n=40).The mice in MCAO group were used to establish the MCAO model by intraluminal occlusion using monofilament.Twenty-four hours after operation,the neurologic function was evaluated and the infarct volume was calculated by TTC staining.Thirty days after operation,Morris water maze test was carried out to investigate spatial learning and memory of the mice.Ninety days after operation,head MRI scan was conducted.Results: In the MCAO group,the satisfactory MCAO model was successfully generated in 67.5% out of the operated mice.The neurological deficit score was(2.36±0.21) and the relative infarct volume was(25.36±3.65) % in the MCAO group.The mice in the sham group performed better in water maze task than those in the MCAO group.T2-weighted MRI imagines showed infarct clearly.Conclusion: Intraluminal occlusion of MCA using monofilament is a kind of simple and reliable method to establish mouse MCAO model." @default.
- W2377937117 created "2016-06-24" @default.
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- W2377937117 date "2012-01-01" @default.
- W2377937117 modified "2023-09-28" @default.
- W2377937117 title "Modification of Generating Middle Cerebral Artery Occlusion Model in Mice" @default.
- W2377937117 hasPublicationYear "2012" @default.
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