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- W2377978215 abstract "Objective To determine the effect of activated Schwann cells for repairing of peripheral nerve defect. Methods Median nerve defect at the forearm (12 mm) in rats was repaired with activated Schwann cells within silicone tube or fresh nerve graft or silicone tube only respectively. Wet muscle weight and tension of the forearm flexors were checked 12 weeks postoperatively. Peripheral nerve regeneration was evaluated by computer image analysis, S 100 protein staining, mono clone antibody neurofilament staining and proliferation cell nuclear antigen (PCNA) immunohistochemical labeling. Results The recovery of nerve regeneration and muscle tension in activated group was superior to that in control group, with statistically significant difference. In activated group, wet muscle weight, tetanic tension and twitch tension was (88.23 ± 6.08) %, (101.34 ± 47.62)%, and (93.48 ± 15.72)% respectively. PCNA indicated the regenerating muscle cells are most in number. Computer image analysis demonstrated the number of regenerating axons was (3 814 ± 522) and the average axon area was 23.70 μm 2. S 100 protein staining, mono clone antibody neurofilament staining implicated that the regenerating nerve of activated group was superior to that of any other groups. Conclusions With respect to the recovery of nerve regeneration and twitch tension, activated Schwann cells filled within silicone tube was superior to autogenous nerve graft and silicone tube only for repair of median nerve defect .It was a new and effective strategy for repair of peripheral nerve defect." @default.
- W2377978215 created "2016-06-24" @default.
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- W2377978215 date "2000-01-01" @default.
- W2377978215 modified "2023-09-25" @default.
- W2377978215 title "Activated Schwann cells filled within silicone tube to repair peripheral nerve defect:a preliminary experimental study" @default.
- W2377978215 hasPublicationYear "2000" @default.
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