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- W2377991732 abstract "【Objective】To investigate the effect of Rapamycin, a inhibitor of the mTOR, on the viability of the colon carcinoma cell line Lovo. 【Methods】The cultured Lovo cells were treated with different concentrations of Ra- pamycin (0.5, 1.0, 2.5 and 5.0 μg/ml) for different time. The proliferation of Lovo cells was detected by MTT method. Cell apoptosis was detected by flow cytometry. The levels of Bcl-2 protein were determined by Western blot. 【Results】Rapamycin inhibited the proliferation of Lovo cells in a concentration- and timedependent manner. Rapamycin induced the apoptosis of Lovo cells in a concentration-dependent manner. The levels of Bcl-2 protein were reduced gradually with the increase of concentration or action time. 【Conclusion】Rapamycin can induce the apoptosis of the colon carcinoma cell line Lovo, reduce the expression of Bcl-2, and inhibite the proliferation of colon carcinoma." @default.
- W2377991732 created "2016-06-24" @default.
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- W2377991732 date "2009-01-01" @default.
- W2377991732 modified "2023-09-25" @default.
- W2377991732 title "Rapamycin inhibited the proliferation of colon cancer cell line Lovo in vitro" @default.
- W2377991732 hasPublicationYear "2009" @default.
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