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- W2378017462 abstract "OBJECTIVE:To investigate the protection mechanism of glutathione peroxidase(GPx) mimics 2-tellurium bridged cyclodextrins(2-TeCD) to human neuroblastoma SH-SY5Y cells damage induced by hydrogen peroxide.METHODS: By using the different concentration hydrogen peroxide(H2O2) induced SH-SY5Y cells,the median lethal concentration(IC50) was detected.The cell survival rate,lipid peroxidation(MDA) and DNA splitting rate were also determined in the different concentrations of 2-TeCD on the H2O2-induced SH-SY5Y cells.RESULTS: The IC50 for H2O2 respons to SH-SY5Y cells was 0.208 mmol/L.The survival rate of SH-SY5Y cell was 52.67% of that of control group ofter treated with 0.2 mmol/L H2O2.The cell survival rate assay results showed that the concentration of 10 μmol/L 2-TeCD could protect H2O2-induced damage SH-SY5Y cells effectively.MDA content and DNA splitting rate of SH-SY5Y cells were also decreased in 10 and 20 μmol/L 2-TeCD.CONCLUSION: The 2-TeCD can effectively protect the SH-SY5Y cells from the H2O2,and it can be a potential antioxidant drugs." @default.
- W2378017462 created "2016-06-24" @default.
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- W2378017462 date "2012-01-01" @default.
- W2378017462 modified "2023-09-23" @default.
- W2378017462 title "Protective effects of 2-TeCD on hydrogen peroxide-induced damage in SH-SY5Y human neuroblastoma cells" @default.
- W2378017462 hasPublicationYear "2012" @default.
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