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- W2378023095 abstract "Objective:To investigate the protective effect of high-dose Angelica sinensis on nerve injury and its impact on the myeloperoxidase(MPO) expression in brain tissue among rats with cerebral ischemia/reperfusion(I/R) injury.Methods:A total of 100 Wistar rats were randomly divided into sham operation group,model group,and low-dose,middle-dose,and high-dose Angelica sinensis groups.A rat model of middle cerebral artery I/R was induced in all groups except the sham operation group.The low-dose,middle-dose,and high-dose Angelica sinensis groups received Angelica sinensis by gavage after reperfusion.The neurological deficit score and MPO content were measured before and after treatment.Results:Before treatment,the model group and high-dose,middle-dose,and low-dose Angelica sinensis groups had significantly higher neurological deficit scores than the sham operation group(P0.01).After treatment,the neurological deficit scores decreased significantly in the high-dose,middle-dose,and low-dose Angelica sinensis groups and model group(P0.01),and the low-dose and middle-dose Angelica sinensis groups had significantly higher neurological deficit scores than the high-dose Angelica sinensis group(P0.01).The MPO activity in brain tissue of rats in each group were compared to results,the sham operation group had the lowest MPO activity;the MPO activity increased significantly in the model group;the high-dose,middle-dose,and low-dose Angelica sinensis groups had significantly lower MPO activity than the model group(P0.01),and the MPO activity was significantly higher in the low-dose Angelica sinensis group than in the middle-dose and high-dose Angelica sinensis groups(P0.05 or P0.01).Conclusion:Angelica sinensis has protective effect on nerve injury after cerebral I/R in rats,and the protective effect improves as the dose of Angelica sinensis increases." @default.
- W2378023095 created "2016-06-24" @default.
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- W2378023095 date "2013-01-01" @default.
- W2378023095 modified "2023-09-23" @default.
- W2378023095 title "Experimental study on effect of high-dose Angelica sinensis on myeloperoxidase expression in rats with cerebral ischemia/reperfusion injury" @default.
- W2378023095 hasPublicationYear "2013" @default.
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