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- W2378024348 abstract "Purpose To study the inhibitory effect of cinnamon acid germanium on growth of uterocervical carcinoma (U14) cell in mouse and its underlying mechanism at the molecular level. Methods The anti-neoplasm activity experimental study was adopted in vivo,The detail procedures were as follows:mice transplanted with U14 cells were divided into groups and O.P. for 10 days. Tumor growth and inhibitory rate,spleen index and thymus index were calculated. A microscopic analysis was performed with HE stain,and pathological changes of all organs were observed in every group. Immunohistochemistry,and methyl green-pyronine stain were also conducted to distinguish the apoptosis cell and necorsis cell; flow cytometry (FCM) was carried out to determine DNA content of tumor cells and apoptotic rate. Results The tumor weights induced by cinnamon acid germanium (3 mg/ml) and CTX were obviously decreased with an inhibitory rate of 46.65% and 54.27% respectively,and FCM showed that apoptotic rate was 22.65% and 20.61%,respectively; A sub-G1 peak appeared in the front of G0-G1 period (apoptosis peak),but no such a peak in NS group. In addition,cinnamon acid germanium had obvious influence on the tumor cell cycle:G2-M period shortened,cell cycle lengthened,and cell proliferation inhibited. Conclusion Cinnamon acid germanium (3 mg/ml) has inhibitory effect on uterocervical carcinoma (U14) cells in mice,leading the tumor cells to apoptosis,which may be the main machinism of the growth inhibition of U14 cells." @default.
- W2378024348 created "2016-06-24" @default.
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- W2378024348 date "2010-01-01" @default.
- W2378024348 modified "2023-09-23" @default.
- W2378024348 title "Inhibitory effect of cinnamon acid germanium on growth of uterocervical carcinoma (U_(14)) cells in mice" @default.
- W2378024348 hasPublicationYear "2010" @default.
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