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- W2378025252 abstract "Objective To study the expression and variation of c fos mRNA in neurons in the visual cortex of kittens with strabismic amblyopia before and after the treatment. Methods Fifteen normal kittens were randomly divided into three groups,surgery to produce iatrogenic convergent strabismus was performed on 9 kittens at 4 weeks of age and 3kittens of those were stimulated by ambient light with the non deviated eye occluded after 4 weeks;Six kittens were used as controls. Using the technique of in situ hybridization, we detected the expression of c fos mRNA of different cats. And pattern visual evoked potential(P VEP), was recorded simultaneously on the 15 kittens throughout experiment.Results In the 17 area of the visual cortex, c fos mRNA positive neurons were observed to decrease at 8 weeks ( P 0.01) but increase after 4 week treatment. The result consists with pattern reversal visual evoked potential(PRVEP) in reflecting the neural activity. Conclusion The change of expression of c fos mRNA in neurons in terms of neural activity before and after treatment verify the molecular biologic basis of electrophysiologic defects as well as morphologic change in the visual cortex. The c fos mRNA can serve as molecular biological index in assessing exciting state of visual cortex." @default.
- W2378025252 created "2016-06-24" @default.
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- W2378025252 date "2003-01-01" @default.
- W2378025252 modified "2023-09-25" @default.
- W2378025252 title "Changes in c-fos gene expression in the visual cortex of kittens with strabismic amblyopia before and after treatment" @default.
- W2378025252 hasPublicationYear "2003" @default.
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