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- W2378028674 abstract "Objective To study the relationship between serum iron,serum ferritin and indicators of hepatic fibrosis of patients with viral hepatitis.Methods The liver specimens of 39 patients with viral hepatitis and 30 subjects of negative viral marker were obtained by 1 s liver biopsy.The specimens were stained by haematoxylin-eosin(HE) and Perl's Prussian.The serum levels of iron,ferritin,hyaluronic acid(HA),laminin(LN),human procollagen type Ⅲ(HPC-Ⅲ),collagen type Ⅳ(Ⅳ-C) were examined by atomic absorption spectrum,radioimmunoassay and enzyme-linked immunosorbent assay(ELISA),respectively.Results Compared with healthy people,serum levels of iron and ferritin in patients with viral hepatitis were significantly different(P0.05).The level of the indicators of hepatic fibrosis in patients with viral hepatitis had statistic value compared with the normal group.There were correlations between serum iron,serum ferritin and serum collagen type Ⅳ(serum iron:r=0.614,P=0.026;serum ferritin:r=0.549,P=0.019).Most of the patients with viral hepatitis had iron overload.Compared with the healthy people,iron of liver obviously increased in patients with viral hepatitis.There were a positive relationship between liver functional lesion and iron deposition in liver tissue.Conclusion The serum levels of iron and ferritin may be the important markers of liver iron overload." @default.
- W2378028674 created "2016-06-24" @default.
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- W2378028674 date "2007-01-01" @default.
- W2378028674 modified "2023-09-26" @default.
- W2378028674 title "Relationship between serum iron,serum ferritin and hepatic fibrosis indicators in patients with viral hepatitis" @default.
- W2378028674 hasPublicationYear "2007" @default.
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