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- W2378045339 abstract "ABSTRACT AIM To study the effect and its molecular mechanism of All-trans Retinoic Acid (ATRA) on tumor invasion and to find a new target of anti-tumor drug. METHODS A high proliferation, scatter, and invasion Hepatoma 7402 cell line with high Ets-1 experssion was set up by transgenic method. Then to study the biological changes on the transgenic cell line treated with ATRA or without using cellar biological methods. Using molecular methods such as northern blot and western blot etc, to study its molecular mechanism. RESULTS An inhibitory effect of ATRA on the proliferation and invasion of the Hepatoma 7402 cell was found. ATRA were also found to down-regulate the expression of Ets and c-Met in the 7402-cell line. The phosphorylation of Erk and Akt were decreased in the cells treated with AT-RA. CONCLUSION ATRA may inhibit the 7402 cell growth and metastasis through down-regulation the expression of Ets and c-Met, then block the MAPK and PI3K signal pathway. Ets may be a target of anti-tumor drug." @default.
- W2378045339 created "2016-06-24" @default.
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- W2378045339 date "2003-01-01" @default.
- W2378045339 modified "2023-09-24" @default.
- W2378045339 title "Inhibitory effect and its molecular mechanism of all-tans retinoic acid on hepatoma 7402 cell's scatter and invasion induced by transcription factor Ets-1" @default.
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