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- W2378045496 abstract "Objective The present study was to determine the effect of sonic hedgehog(Shh) and its receptor Ptc1 on delayed wound healing in type 1 diabetic mice.Methods The skin wound models in normal and streptozotocin(STZ)-induced type 1 diabetic mice were used.Protein levels of both Shh and Ptc1 in skin tissues were determined using Western blotting;the effects of exogenous Shh or Ptc1 blocker cyclopamine on wound healing were observed.Results(1) In normal mice,the protein expressions of both Shh and Ptc1 were markedly increased after wounding.Exogenous Shh had no effects on wound healing;however,cyclopamine significantly decreased the wound healing in normal mice.(2) The protein levels of Shh and Ptc1 in skin tissues were significantly decreased in diabetic mice compared to normal mice.(3) Exogenous Shh accelerated the wound healing of diabetic mice in a dose-dependent manner.Cyclopamine significantly inhibited the wound healing in diabetic mice.Conclusion Shh-Ptc1 pathway is involved in skin wound healing, and the delayed wound healing in diabetes may be related to the downregulation of Shh-Ptc1." @default.
- W2378045496 created "2016-06-24" @default.
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- W2378045496 date "2007-01-01" @default.
- W2378045496 modified "2023-09-26" @default.
- W2378045496 title "Delayed wound healing in type 1 diabetic mice improved by sonic hedgehog" @default.
- W2378045496 hasPublicationYear "2007" @default.
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