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- W2378049187 abstract "Objective To investigate the relationship between serum insulin-like growth factor-Ⅰ (IGF-Ⅰ) level and liver disease. Methods The serum IGF-Ⅰ levels in 73,57 and 30 patients with chronic hepatitis(CH), liver cirrhosis(LC) and chronic severe hepatitis(CSH) respectively, and 30 healthy controls were detected by enzyme linked immunosorbent assay (ELISA). LC patients were divided into three groups(group A, 19 patients; B, 17 patients and C, 21 patients) according to Child-pugh score. Results The serum IGF-Ⅰ levels in patients with CH, LC and CSH were( 199.0± 40.8) ng/ml,( 105.3± 57.5) ng/ml and ( 48.9± 33.2) ng/ml respectively, and decreased significantly compared with that in controls[( 275.09± 98.99) ng/ml, P 0.001]. The serum IGF-Ⅰ levels in patients with different liver disease also were significantly different. IGF-Ⅰ level in CSH group was significantly lower than that in LC group (P 0.001), and the latter was significantly lower than that in CH group(P 0.001). As the Child-pugh score increased, the serum IGF-Ⅰ concentration was decreased significantly in LC patients. Conclusions The level of serum IGF-Ⅰ is related with the severity of liver disease." @default.
- W2378049187 created "2016-06-24" @default.
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- W2378049187 date "2005-01-01" @default.
- W2378049187 modified "2023-09-27" @default.
- W2378049187 title "Study on the relationship of insulin-like growth factor-I and liver disease" @default.
- W2378049187 hasPublicationYear "2005" @default.
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