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- W2378052124 abstract "Objective To study the changes and clinical significance of plasma von Willebrand factor(vWF),D-dimer(D-D) and platelet parameters in patients of hemorrhagic fever with renal syndrome(HFRS).Methods According to the severity of disease,18 cases with HFRS were divided into two groups(moderate group and severe group,each group 9 cases),and 20 healthy individuals served as control group.Blood samples were collected at every stage of the disease,plasma vWF was detected by enzyme-linked immunosorbent assay(ELISA),plasma D-D by latex-enhanced turbidimetric immunoassay,blood urea nitrogen(BUN),creatinine(Cr),alanine aminotransferase(ALT) and aspartate transaminase(AST) by automatic biochemical analyzer,and platelets by automated hematologic analyzer.Results Compared with control group,the plasma levels of vWF and D-D were significantly higher through the disease course with pick values in febrile and hypotension-oliguric stage of HFRS,vWF(363.69±54.30) μg/L vs(170.40±29.35) μg/L(P0.01);D-D(4.17±2.66) μg/L vs(0.17±0.07) μg/L(P0.01).There was no significant difference in plasma vWF levels between moderate group and severe group,but significant difference was observed in plasma D-D levels during hypotension-oliguric stage,(4.17±2.66) μg/L vs(1.88±0.48) μg/L(P0.01).The variation curve of D-D was in line with that of BUN,ALT and AST,but was contrary to blood platelet count.Conclusion Significantly elevated plasma levels of vWF and D-D and decreased blood platelet count coincident with hepatic and renal dysfunction were observed in the acute phase of HFRS,suggesting the presence of extensive capillary injury associated with activation of coagulation system.Accordingly,it is important in the early stage to use anticoagulants such as low molecular mass heparin to improve microvascular disturbance and to alleviate multiple organ damage." @default.
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- W2378052124 date "2013-01-01" @default.
- W2378052124 modified "2023-09-24" @default.
- W2378052124 title "Changes and clinical significance of plasma von Willebrand factor, D-dimer and platelet parameters in patients of hemorrhagic fever with renal syndrome" @default.
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