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- W2378059611 abstract "Objective To investigate the changes of liver pathology,serum cytokines IFN-γ,IL-10 and HBV DNA levels in patients with chronic hepatitis B(CHB)before and after treatment with adefovir dipivoxil(ADV). Methods A total of 18 CHB patients were enrolled and treated with adefovir dipivoxil for 48 weeks.The levels of cytokines IFN-γand IL-10 before and after treatment were assessed by ELISA.The liver tissue was dyed with HE dyeing,Masson dyeing,Nets dyeing and VG dyeing.The HBV DNA level of serum was detected by real-time fluorescent quantitative PCR.Results The levels of cytokines IFN-γand IL-10 in CHB patients before ADV treatment were significantly lower than those in the control group(P0.05).After 48-week treatment with ADV, the levels of cytokines IFN-γand IL-10 were significantly higher than those before(P0.05).The levels ofcytokines IFN-γand IL-10 in CHB patients after ADV treatment were lower than those in the control group,but only the difference in IFN-γwas significant(P0.05).After 48-week treatment,the levels of serum ALT and HBV DNA were significantly lower than those before(P0.05).Liver pathology was improved after 48-week ADV treatment;especially inflammation of the liver tissue was obviously improved,the difference between before and after treatment was significant(P0.05).Fibrosis degree of the liver tissue was improved,without significant difference between before and after treatment.After ADV treatment,higher level of IFN-γwas found in the group whose liver tissue inflammation was obvious(G≥3 level)before ADV treatment than the other group whose liver tissue inflammation was not obvious(G≤2level);the difference between before and after treatment was significant(P0.05).The negative rate of serum HBV DNA was 88.89%in the former group and 55.56%in the latter, respectively,but without significant difference(P0.05).Conclusion ADV may improve the imbalanced expression of cytokines IFN-γand IL-10 and ameliorate the immunity of CHB patients.The therapeutic effect will be much better if inflammation of the liver tissue is obvious before treatment." @default.
- W2378059611 created "2016-06-24" @default.
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- W2378059611 date "2014-01-01" @default.
- W2378059611 modified "2023-09-26" @default.
- W2378059611 title "Changes of serum cytokines IFN-γ,IL-10 and HBV DNA levels and liver pathology in patients with chronic hepatitis B before and after treatment with Adefovir dipivoxil" @default.
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