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- W2378059651 abstract "Objective To investigate the effect of montelukast on urine leukotrienes in asthmatic children with mycoplasma pneumoniae (MP)infection.Methods The serum MP-IgM antibody was detected by passive agglutination in 200 asthmatic cases and 50 normal subjects. According to the results of MP-IgM antibody examination,asthmatic cases were divided into four groups of A (32 cases) with MP-IgM positive and the treatment of montelukast,B (32 cases) with MP-IgM positive and the conventional treatment without montelukast,C(32 cases) with MP-IgM negative and the treatment with montelukast,and D (32 cases) with MP-IgM negative and the conventional treatment without montelukast. The urine leukotriene level before and after treatment was detected by ELISA. Results Urine leukotriene in MP-IgM positive cases(group A and B) was higher than that in the MP-IgM negative(group C and D) before therapy [(0.51±0.26)ng/ml vs.(0.38±0.11)ng/ml](P0.01). After treatment,urine leukotriene was significantly decreased in groups of A and C compaered with that before [(0.25±0.20)ng/ml vs.(0.50±0.26)ng/ml(P0.01)and (0.22±0.10)ng/ml vs.(0.35±0.15)ng/ml,respectively (P0.05)],which was lower in group A than that in group B [(0.25±0.20)ng/ml] vs.(0.42±0.15)] (P0.01).Conclusion MP infection can induce an increase of urine leukotriene level in asthmatic children,which can be reduced by administration of montelukast." @default.
- W2378059651 created "2016-06-24" @default.
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- W2378059651 date "2009-01-01" @default.
- W2378059651 modified "2023-09-24" @default.
- W2378059651 title "Effect of montelukast on urine leukotrienes in asthmatic childrenwith mycoplasma pneumoniae infection" @default.
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