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- W2378067796 abstract "Objective To investigate the effect of rosuvastatin on AKT/P-AKT expression in LDLR-/- mice with atherosclerosis induced by insulin resistance.Methods Forty-five LDLR-deficient mice at 6 weeks of age were randomized into 5 groups(n =8 in each group):control group(NC group),high fat diet group(HF group),high fat and high fructose diet group(HFF group),rosuvastatin intervention groups(HFFR group),rosuvastatin and mevalonic acid intervention group(HFFRMA group).High fat and high fructose diet were given to establish the mouse model with atherosclerosis induced by insulin resistance.The plasma levels of the TC,TG,LDL-C,HDL-C,FBS and FINS were measured after 12 weeks;the morphological of the aorta artery and aorta sinus was examined and the expression of AKT and P-AKT in liver,cardiac muscle,aorta arch was detected.Results Plasma levels of FBS,FINS,HOMA-IR,TC,TG and LDL-C in HFF group were markedly higher than those in other groups(P 0.05),and HDL-C level was significantly decreased(P 0.05).Contrast to HFF group,in HFFR group all above indexes were significantly improved(P 0.05).Plasma TC and LDL-C level showed no significant difference between HFF and HFFRMA group(P 0.05).The area of atherosclerotic plaque in HFF was significantly increased than that of other groups(P 0.05).The area of atherosclerotic plaque in HFFR and HFFRMA group decreased remarkably,and showed no significant difference between the two groups(P 0.05).The AKT,P-AKT expressions in HFF group were significantly lower than those in other groups(P 0.05 ).Compared with HFF group the expression of AKT and P-AKT in HFFR and HFFRMA groups was up-regulated;there were no differences between HFFR and HFFRMA groups.Conclusion High fat and high fructose diet can induce insulin resistance in LDLR-/- mice.Insulin resistance may accelerate the development of atherosclerosis and inhibit the expression of AKT and P-AKT in liver,cardiac muscle and aorta arch. Rosuvastatin can prevent the development of insulin resistance and atherosclerosis,which may be associated with up-regulation of AKT and P-AKT expression." @default.
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- W2378067796 date "2012-01-01" @default.
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- W2378067796 title "Effect of rosuvastatin on AKT/P-AKT expression in LDLR-/- mice with atherosclerosis induced by insulin resistance" @default.
- W2378067796 hasPublicationYear "2012" @default.
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