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- W2378079551 abstract "Objective To investigate the efficacy and safety of edaravone-defibrase combination in treatment of acute cerebral infarction.MethodsThe patients with acute cerebral infarction within 12 hours of stroke onset were divided randomly into two groups:group A(46 cases)and group B(47 cases).Group A were treated with edaravone(30 mg,twice a day,for 14 days)and defibrase(initial 15U,subsequent 5U on the 3th,5th,7th,9th day);and group B were treated only with defibrase.The neurological deficit scores of European stroke scale(ESS),activities of daily living(ADL),APACHE Ⅱ scores and C-reactive protein(CRP)level were evaluated before and after treatment;the efficacy was evaluated after the treatment.ResultsAfter the 14th day treatment,there were significant difference of all the four variables(ESS,ADL,APACHE Ⅱ and CRP)in two groups than before treatment,all the four variables of group A were better than group B;the efficient rate of group A(67.4%)was higher than group B(40.4%)(P0.05);there was no significant difference for the mortality at 3 months between two groups(P0.05);There were several patients with extracranial hemorrhage and there was no significant difference between two groups(P0.05),there was no intracranial hemorrhage in all patients;there was no severe adverse reaction in two groups.ConclusionEdaravone-defibrase combination is effective and safe in treatment of acute cerebral infarction." @default.
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- W2378079551 date "2008-01-01" @default.
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- W2378079551 title "Clinical study of edaravone-defibrase combination in treatment of acute cerebral infarction" @default.
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