Matches in SemOpenAlex for { <https://semopenalex.org/work/W2378082801> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2378082801 abstract "We investigated roles of methylation In bac- terial chemotaxis by characterizing a methyl-accepting trans- ducer protein incapable of methylation because of amino acid substitutions at the modification sites. Mutant Trg protein recognized ligand and generated excitatory signals that affected flagella but was unable to mediate efficient adaptation or net cellular migration in a relevant chemical gradient. Defects caused by lack of methyl-accepting sites on Trg were sup- pressed by a suffi'cient cellular content of other transducer molecules with functional methyl-accepting sites. These obser- vations establish directly that methylation Is crucial for trans- ducer-mediated chemotaxis and that neither phosphotransfer reactions among the soluble Che proteins nor other interaction among those chemotactic components can effectively fulfill the functions of methylation. Suppression was correlated with adaptational crosstalk in which unoccupied methyl-accept- ing transducers acquired methyl groups, thus apparently substituting effectively for blocked methyl-accepting sites on the transducer. A plausible model for this phenomenon Is that increased methylation of unstimulated transducers results from global inhibition of the demethylating enzyme in a cell with a normally active methyltransferase and no available methyl-accepting sites on the stimulated, mutant transducer. Thus methylation can perform its roles in adaptation and gradient sensing even if modification occurs on molecules different from those that recognize the stimulating compound. This observation emphasizes the central role of methylation and the modular nature of the chemosensory system." @default.
- W2378082801 created "2016-06-24" @default.
- W2378082801 creator A5042331909 @default.
- W2378082801 creator A5051475312 @default.
- W2378082801 creator A5054850739 @default.
- W2378082801 date "2016-01-01" @default.
- W2378082801 modified "2023-10-13" @default.
- W2378082801 title "Adaptational crosstalk and the crucial role of methylation in chemotactic migration by Escherichia coli (sensory transduction/transmembrane receptor proteins/protein covalent modification/site-specific mutagenesis/bacterial chemotaxis)" @default.
- W2378082801 cites W2127989785 @default.
- W2378082801 hasPublicationYear "2016" @default.
- W2378082801 type Work @default.
- W2378082801 sameAs 2378082801 @default.
- W2378082801 citedByCount "0" @default.
- W2378082801 crossrefType "journal-article" @default.
- W2378082801 hasAuthorship W2378082801A5042331909 @default.
- W2378082801 hasAuthorship W2378082801A5051475312 @default.
- W2378082801 hasAuthorship W2378082801A5054850739 @default.
- W2378082801 hasConcept C104317684 @default.
- W2378082801 hasConcept C120665830 @default.
- W2378082801 hasConcept C121332964 @default.
- W2378082801 hasConcept C169822122 @default.
- W2378082801 hasConcept C170493617 @default.
- W2378082801 hasConcept C185592680 @default.
- W2378082801 hasConcept C24530287 @default.
- W2378082801 hasConcept C2778178838 @default.
- W2378082801 hasConcept C33288867 @default.
- W2378082801 hasConcept C54166955 @default.
- W2378082801 hasConcept C55493867 @default.
- W2378082801 hasConcept C62478195 @default.
- W2378082801 hasConcept C86803240 @default.
- W2378082801 hasConcept C91965660 @default.
- W2378082801 hasConcept C95444343 @default.
- W2378082801 hasConceptScore W2378082801C104317684 @default.
- W2378082801 hasConceptScore W2378082801C120665830 @default.
- W2378082801 hasConceptScore W2378082801C121332964 @default.
- W2378082801 hasConceptScore W2378082801C169822122 @default.
- W2378082801 hasConceptScore W2378082801C170493617 @default.
- W2378082801 hasConceptScore W2378082801C185592680 @default.
- W2378082801 hasConceptScore W2378082801C24530287 @default.
- W2378082801 hasConceptScore W2378082801C2778178838 @default.
- W2378082801 hasConceptScore W2378082801C33288867 @default.
- W2378082801 hasConceptScore W2378082801C54166955 @default.
- W2378082801 hasConceptScore W2378082801C55493867 @default.
- W2378082801 hasConceptScore W2378082801C62478195 @default.
- W2378082801 hasConceptScore W2378082801C86803240 @default.
- W2378082801 hasConceptScore W2378082801C91965660 @default.
- W2378082801 hasConceptScore W2378082801C95444343 @default.
- W2378082801 hasLocation W23780828011 @default.
- W2378082801 hasOpenAccess W2378082801 @default.
- W2378082801 hasPrimaryLocation W23780828011 @default.
- W2378082801 hasRelatedWork W1968689433 @default.
- W2378082801 hasRelatedWork W1976214976 @default.
- W2378082801 hasRelatedWork W1984843090 @default.
- W2378082801 hasRelatedWork W2001296414 @default.
- W2378082801 hasRelatedWork W2016575278 @default.
- W2378082801 hasRelatedWork W2018554782 @default.
- W2378082801 hasRelatedWork W2029895867 @default.
- W2378082801 hasRelatedWork W2064891232 @default.
- W2378082801 hasRelatedWork W2071526531 @default.
- W2378082801 hasRelatedWork W2073789853 @default.
- W2378082801 hasRelatedWork W2102685650 @default.
- W2378082801 hasRelatedWork W2105651892 @default.
- W2378082801 hasRelatedWork W2119064690 @default.
- W2378082801 hasRelatedWork W2128481036 @default.
- W2378082801 hasRelatedWork W2169438998 @default.
- W2378082801 hasRelatedWork W2443737163 @default.
- W2378082801 hasRelatedWork W2626686003 @default.
- W2378082801 hasRelatedWork W2713223939 @default.
- W2378082801 hasRelatedWork W2906117247 @default.
- W2378082801 hasRelatedWork W873335149 @default.
- W2378082801 isParatext "false" @default.
- W2378082801 isRetracted "false" @default.
- W2378082801 magId "2378082801" @default.
- W2378082801 workType "article" @default.