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- W2378082802 abstract "AIM To investigate epidermal growth factor receptor (EGFR) and transforming growth factor (TGF ) expressions in 3 kinds of different specimens from 14 patients with colorectal carcinoma, and inquire into their actions in the occurrence and growth of colorectal carcinoma. METHODS The specimens were 2cm2cm whole layer intestine tissue, and harvested in the areas of the tumor, the paratumor area(2cm away from the tumor)and the distal area (10cm away from the tumor) from 14 patients with colorectal carcinoma. Northern blot assay was used to investigate the expressions of EGFR and TGF mRNA. RESULTS EGFR and TGF mRNA were expressed in 3 groups of the specimens from 14 patients. The expressed mRNAs in the paratumor area were higher than in the tumor and distal area, in the same cases, mRNAs expression showed the decreasing tendency in the distal area. The hybrizing signals in 3 cases of A and B stage were lower than that in 11 cases of C or D stage. CONCLUSION EGFR and TGF play a key role in oncogenesis of colorectal carcinoma, and the expression of EGFR, TGR mRNA correlate with Dukes'stage. They might be used to show the malignancy of colorectal carcinoma. Whether the decreased expression of EGFR and TGF in the distal area might serve as an index in evaluating the excision area for the tumor in clinical practice needs further investigations." @default.
- W2378082802 created "2016-06-24" @default.
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- W2378082802 date "1999-01-01" @default.
- W2378082802 modified "2023-09-23" @default.
- W2378082802 title "Expression significance of epidermal growth factor receptor and transforming growth factor mRNA in human colorectal carcinoma" @default.
- W2378082802 hasPublicationYear "1999" @default.
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