Matches in SemOpenAlex for { <https://semopenalex.org/work/W2378085391> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2378085391 abstract "Objective To study the anti-complementary anthraquinones from Polygonum cuspidatum and their action targets.Methods The anti-complementary activity-directed isolation was carried out with the hemolysis test as guide. All isolates were evaluated for their in vitro anti-complementary activities. The action targets of the main bioactive constituents were also examined using complement-depleted sera. Results Ten anthraquinones and three other compounds were isolated from the EtOAc fraction of P.cuspidatum extract, including physcion(1), chrysophanol(2), questin(3), emodin-8-O-β-D-glucoside(4), emodin(5), rhein(6),fallacinol(7), citreorosein(8), xanthorin(9), isorhodoptilometrin(10), 2, 5-dimethyl-7-hydroxychromone(11), 7-hydroxy-4-methoxy-5-methylcoumarin(12), and 5, 7-dihydroxy-1-isobenzofuranone(13). Compounds 9 and 10 were isolated from the the plants of Polygonaceae for the first time, and compound 9 was the alizarin-type anthraquinone first obtained from P. cuspidatum. Compounds3—9 showed the anti-complementary activity in different degrees, and compound 7 exhibited the most significant activity against the classical and alternative pathway [CH50=(6 ± 2) μg/mL, AP50=(50 ± 5) μg/mL]. The study on the preliminary mechanism revealed that compound 4 interacted with C1q, C2, and C9 in complement activation cascade, while compound 7 acted on C1q, C2, C4, and C9.Conclusion The anthraquinones are main anti-complementary constituents in P. cuspidatum; and fallacinol(7) is a potential complement inhibitor with strong activity and definite targets, which should be further studied in future." @default.
- W2378085391 created "2016-06-24" @default.
- W2378085391 creator A5043365752 @default.
- W2378085391 date "2013-01-01" @default.
- W2378085391 modified "2023-09-26" @default.
- W2378085391 title "Anti-complementary anthraquinones from Polygonum cuspidatum and their action targets" @default.
- W2378085391 hasPublicationYear "2013" @default.
- W2378085391 type Work @default.
- W2378085391 sameAs 2378085391 @default.
- W2378085391 citedByCount "0" @default.
- W2378085391 crossrefType "journal-article" @default.
- W2378085391 hasAuthorship W2378085391A5043365752 @default.
- W2378085391 hasConcept C111684460 @default.
- W2378085391 hasConcept C159654299 @default.
- W2378085391 hasConcept C171279029 @default.
- W2378085391 hasConcept C178790620 @default.
- W2378085391 hasConcept C185592680 @default.
- W2378085391 hasConcept C203014093 @default.
- W2378085391 hasConcept C2778248515 @default.
- W2378085391 hasConcept C2778913731 @default.
- W2378085391 hasConcept C2780867653 @default.
- W2378085391 hasConcept C2781136998 @default.
- W2378085391 hasConcept C55493867 @default.
- W2378085391 hasConcept C556039675 @default.
- W2378085391 hasConcept C59822182 @default.
- W2378085391 hasConcept C71240020 @default.
- W2378085391 hasConcept C71924100 @default.
- W2378085391 hasConcept C86803240 @default.
- W2378085391 hasConceptScore W2378085391C111684460 @default.
- W2378085391 hasConceptScore W2378085391C159654299 @default.
- W2378085391 hasConceptScore W2378085391C171279029 @default.
- W2378085391 hasConceptScore W2378085391C178790620 @default.
- W2378085391 hasConceptScore W2378085391C185592680 @default.
- W2378085391 hasConceptScore W2378085391C203014093 @default.
- W2378085391 hasConceptScore W2378085391C2778248515 @default.
- W2378085391 hasConceptScore W2378085391C2778913731 @default.
- W2378085391 hasConceptScore W2378085391C2780867653 @default.
- W2378085391 hasConceptScore W2378085391C2781136998 @default.
- W2378085391 hasConceptScore W2378085391C55493867 @default.
- W2378085391 hasConceptScore W2378085391C556039675 @default.
- W2378085391 hasConceptScore W2378085391C59822182 @default.
- W2378085391 hasConceptScore W2378085391C71240020 @default.
- W2378085391 hasConceptScore W2378085391C71924100 @default.
- W2378085391 hasConceptScore W2378085391C86803240 @default.
- W2378085391 hasLocation W23780853911 @default.
- W2378085391 hasOpenAccess W2378085391 @default.
- W2378085391 hasPrimaryLocation W23780853911 @default.
- W2378085391 hasRelatedWork W1969052483 @default.
- W2378085391 hasRelatedWork W1969474797 @default.
- W2378085391 hasRelatedWork W2005167673 @default.
- W2378085391 hasRelatedWork W200991978 @default.
- W2378085391 hasRelatedWork W2033492693 @default.
- W2378085391 hasRelatedWork W2052529815 @default.
- W2378085391 hasRelatedWork W2269024446 @default.
- W2378085391 hasRelatedWork W2323984521 @default.
- W2378085391 hasRelatedWork W2343950752 @default.
- W2378085391 hasRelatedWork W2347837616 @default.
- W2378085391 hasRelatedWork W2351589825 @default.
- W2378085391 hasRelatedWork W2365300188 @default.
- W2378085391 hasRelatedWork W2377586800 @default.
- W2378085391 hasRelatedWork W2380980163 @default.
- W2378085391 hasRelatedWork W2382581380 @default.
- W2378085391 hasRelatedWork W2385162511 @default.
- W2378085391 hasRelatedWork W2386400261 @default.
- W2378085391 hasRelatedWork W2388640543 @default.
- W2378085391 hasRelatedWork W3024458799 @default.
- W2378085391 hasRelatedWork W3206492075 @default.
- W2378085391 isParatext "false" @default.
- W2378085391 isRetracted "false" @default.
- W2378085391 magId "2378085391" @default.
- W2378085391 workType "article" @default.